Central to Chelation Therapy are potent chelating agents like EDTA, DMSA, or natural products such as glutathione, cilantro, zeolite, bentonite clay, and homeopathics. These agents form bonds with toxic heavy metals embedded in tissues, guiding them through the body's filtration system for safe elimination via urine.

In a notable 2005 study, EBOO treatments were administered to individuals with peripheral artery disease (PAD) as part of a clinical trial to assess their impact on skin lesions. Compared to an alternative treatment, the EBOO group experienced a significant reduction of skin lesions. Alongside the regression of skin issues, those undergoing EBOO reported reduced discomfort and improved overall well-being.

Beyond these applications, ozone therapy has shown promise for patients dealing with fungal/yeast infections, tetanus, chronic fatigue, cardiovascular diseases, eye disorders, skin conditions, respiratory issues, heavy metal poisoning, biotoxin illness, CIRS, mold toxicity, autoimmune diseases, cancer and various other medical conditions.

Extensive research underscores the efficacy of chelation therapy in forming complexes with harmful metal ions for safe removal. Combination therapies and antioxidant co-administration further amplify therapeutic benefits.