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Understanding Chronic Inflammatory Response Syndrome (CIRS)

In this comprehensive article, we will go over everything you need to know about these medical conditions, what a typical treatment is, and how Mitogenesis can help you.

In this comprehensive article, we will go over everything you need to know about these medical conditions, what a typical treatment is, and how Mitogenesis can help you.

A deeper look at biotoxins

Chronic Inflammatory Response Syndrome (CIRS), also known as biotoxin illness, is a group of symptoms, test results, and laboratory findings associated with exposure to biotoxins. It usually appears in genetically susceptible individuals. It's mostly connected to poisons found in buildings that have been damaged by water, poisons that are spread by parasites like ticks, and poisons that are made by bacteria, mold, or other things in the environment.

Mitogenesis has a specialized team led by Dr. Mel Schottenstein that regularly works on the treatment of mitochondrial diseases and the creation of new comprehensive programs for people with CIRS and other related conditions, such as mold illness, Lyme disease, and mast cell activation.

Inhalation in water-damaged building (WDB)

Regular exposure to biotoxins through the respiratory tract over an extended period of time leads to this condition. For instance, this could occur if the patient resides in a water-damaged building (WDB). Water-damaged structures due to lack of maintenance, natural disasters, or lack of hygiene harbor a dangerous mix of various chemicals, mold, bacteria, and inflammatory agents that cause the disease. The combination of elements that trigger systemic inflammation, rather than a single element.

Insect bites (ticks and spiders)

Ticks are a common parasitic insect in dogs, cats, and other animals with which we usually coexist daily. Patients often do not realize that they have been bitten by a tick, which can transmit severe infections, such as Lyme disease (Borrelia burgdorferi) and babesiosis (Babesia microti), among others.

Some species of spiders, for their part, can also transmit infections or inject biotoxins into the body. Patients living in areas frequently bitten by these insects may develop.

Ingestion of biotoxins

Environmental pollution has increased significantly in recent years. Rivers, forests, and seas have high levels of toxins that end up entering the trophic cycle of the foods we regularly consume. The most common example is the fish that inhabited or consumed dinoflagellates, which produce the ciguatoxin.  

Direct contact with contaminated water

CIRS patients may also have been exposed to biotoxins through direct contact with toxin-contaminated water. Generally, the contamination is caused by fish kills that generate Pfiesteria and cyanobacteria. You can also inhale these toxins in the air or from an aerosol source.

Why doesn't the immune system deal with toxins?

Biotoxins enter the human body through inhalation, ingestion, tick or spider bites, or direct contact with contaminated water sources. These toxins can cause acute illnesses in people, but in those patients who are genetically susceptible, they cause chronic diseases.

In a healthy individual with a robust immune system, the body typically recognizes, breaks down, and eliminates toxins. But in people who are genetically more likely to be affected, the immune system doesn't recognize biotoxins. This means that they stay in the body, circulate freely, and cause inflammation in many systems.

Possible symptoms of biotoxins

The inflammation caused by biotoxins generates different types of symptoms that, at first, seem random, which can lead to misdiagnosis by medical personnel who are not familiar with this disease. An analysis that revealed that the symptoms, although they seem random, have common points.

This analysis classifies the symptoms into thirteen distinct groups:

  1. Diarrhea, abdominal pain, and numbness
  1. Nasal congestion; difficulty breathing
  1. Deteriorated memory, difficulty finding words
  1. Increased skin sensitivity; tingling, pins, and needles
  1. Disorientation, metallic taste, and watery eyes
  1. Weakness, body aches, headaches, light sensitivity, and problems learning new information
  1. Blurred vision, night sweats, mood swings, stabbing pain, and red or bloodshot eyes
  1. Deep and persistent fatigue
  1. Problems concentrating
  1. dizziness and static shocks
  1. Extreme thirst, cough, and confusion.
  1. Joint pain, morning stiffness, and muscle cramps
  1. Problems regulating body temperature, frequent urination

Misdiagnosis of biotoxin illness

An erroneous diagnosis is very common, as it shares symptoms with a variety of systemic diseases. The most common are:

  • Chronic Fatigue Syndrome (CFS)
  • Fibromyalgia
  • Depression and anxiety
  • Allergies
  • Somatization
  • Attention Deficit Disorder/Attention Deficit Hyperactivity Disorder (ADD/ADHD)
  • Irritable Bowel Syndrome (IBS)
  • Post-Traumatic Stress Disorder (PTSD)

If you have any of these diseases and the treatment is ineffective or you have any of the thirteen groups of symptoms, Mitogenesis can provide a second opinion.

Diagnostic tests for CIRS

A variety of tests can diagnose to produce the most accurate results. The most common diagnostic tests are:

Visual Contrast Sensitivity Test (VCS)

Biotoxins and the inflammatory response damage nerves, which can cause neurological symptoms like less sensitivity to contrast. According to Dr. Shoemaker's research, this decrease in VCS is due to a reduction in the speed of red blood cell flow reaching the structures of the eye.

Genetic tests: a human leukocyte antigen (HLA) test

The test determines if the patient is genetically susceptible to biotoxins. We perform the generic HLA DR/DQ test. The type of HLA and the immune response determine whether a person will develop the inflammation caused by CIRS.

Biomarker test: transforming growth factor beta-1 (TGF beta-1)

TGF beta-1 is an essential molecule in the control of the immune system. It produces or suppresses inflammation. If the test indicates elevated levels of TGF beta-1, it is a sign of an overactive immune response. Some autoimmune diseases present elevated levels of this molecule.

Contact our Mitogenesis medical expert in Scottsdale, Arizona.

If you have detected the symptoms mentioned or find yourself in a space related to exposure to biotoxins, mold, or high humidity levels, it is time to contact our medical expert. At Mitogenesis Regenerative Medicine, we can find a comprehensive strategy that can transform your life, alleviate inflammatory processes, and detoxify the body to improve overall well-being and quality of life.

If you wish to contact Dr. Mel Schottenstein at Mitogenesis or learn more about the treatments we offer, please call us or fill out a contact form with your information!

Sources:

Chronic inflammatory response syndrome: a review of the evidence of clinical efficacy of treatment (https://pmc.ncbi.nlm.nih.gov/articles/PMC11623837/)

Chronic Inflammatory Response Syndrome (CIRS) (https://www.medicinenet.com/chronic_inflammatory_response_syndrome_cirs/article.htm)

Diagnostic Process for Chronic Inflammatory Response Syndrome (CIRS): A Consensus Statement Report of the Consensus Committee of Surviving Mold (https://www.survivingmold.com/Publications/CIRS_diagnostic_protocol_final_5_1_2018.pdf)

Vasoactive intestinal polypeptide (VIP) correct chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildings (https://www.survivingmold.com/docs/VIP_published_3_2013.pdf)

 

Reviewed by:

Dr. Mel Schottenstein

Naturopathic Doctor

NMD, MBE, MScN, FICT, FSCT

Disclaimer: The information in this article is provided for informational purposes only and is not a substitute for the advice of your physician or other health care professional. Do not use the information to diagnose or treat a health problem or disease. Always consult with a healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem.

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