TruDOSE PRP in Scottsdale: The Next Generation of Personalized Regenerative Therapy

TruDOSE PRP vs. Conventional PRP: What changes, and for whom is it suitable?

PRP in 2025: Overview and Why Dosage Matters

PRP (platelet-rich plasma) is an autologous concentrate: your blood is centrifuged to obtain a fraction with a higher concentration of platelets and signaling factors. In theory, it sounds simple; in practice, no two PRPs are identical, and that variability affects the results. Recently, reviews and studies have insisted that the concentration of platelets, the presence or absence of leukocytes, and the preparation method influence clinical efficacy—and how studies are reported.

Various authors have called for better standardization and reporting of PRP variables. The reason? Without minimal comparable data—final concentration, injected volume, leukocyte content, number of applications—it is complex to draw solid or replicable conclusions.

Variability in traditional PRP (concentration, volume, preparation)

Traditional PRP usually lacks a standard for its application, and the calculations are primarily based on the doctor's instructions and experience. Instructions and experience from the doctor:

• Kits and centrifuges change, as well as the centrifugation time/speed.

• The final volume and platelet concentration can vary, sometimes only slightly exceeding the baseline and other times significantly increasing.

• The leukocyte load can vary between leukocyte-rich and leukocyte-poor PRP, and the results depend on the specific tissue or indication being treated.

In 2024-2025, there are studies showing different effects of platelet concentration on pain and knee function. There are also studies that question the importance of white blood cells in some applications, which again highlights the need for better definition and measurement.

Introduction to TruDOSE: Biometric Dosing and Quality Control

TruDOSE PRP wants to improve the way we calculate doses by using biometric data and AI: it figures out the right amount of platelets needed based on patient information, checks the actual concentration, and adjusts the volume to provide a specific dose instead of just giving "a bit of PRP." At Mitogenesis, we integrate it into personalized plans for persistent pain, recovery, or selected chronic conditions, always with realistic expectations and clinical supervision.

Key differences in procedure and patient experience

A typical consultation with TruDOSE feels less like a "one-size-fits-all" and more like a "custom-tailored suit."

Evaluation and customization flow with AI/biometrics

1. Initial assessment: medical history, objectives (pain, function, sleep, energy), review of comorbidities and medication. Initial assessment: medical history, goals (pain, function, sleep, and energy), and review of comorbidities and medication.

2. Calculation of dosage: Dose calculation: The TruDOSE system uses biometric parameters to estimate the platelet dose we aim to administer. The sample is processed, and the concentration is verified to adjust the final volume.

3. Planning: number of sessions, intervals, and synergies (rehabilitation, nutrition, rest). Organizing: how many sessions, how long they last, and how they work together (rehabilitation, nutrition, rest). No "one-size-fits-all": it is scheduled according to response and functional goals.

4. Follow-up: pain/function scales, activity metrics, and, when appropriate, new measurements to maintain the effective dose in subsequent applications. To maintain the effective dose in later applications, follow-up measures include pain/function scales, activity metrics, and, when necessary, new measurements.

This approach responds to a documented fact: platelet dosage can modify clinical outcomes; therefore, measuring and adjusting matters.

Common indications (chronic pain, injuries, and systemic inflammation)

Cases where TruDOSE PRP is usually considered:

• Chronic musculoskeletal pain (knee, shoulder, tendinopathies), when biological support is sought in addition to physical therapy and load changes.

• Overuse injuries in active individuals who have already optimized technique/rehab and want to explore a regenerative boost.

• Systemic inflammation is selected as part of comprehensive treatments for patients with complex conditions, such as long COVID or mitochondrial problems, and is always used in addition to other therapies after a medical evaluation.

PRP—conventional or TruDOSE—does not replace surgery when it is necessary, nor does it replace habits such as sleep, strength, and nutrition.

What to expect in a session

• Before: hydration, a review of medications, and expectations.

• During the session: blood will be extracted, followed by a centrifugation process and concentration verification in TruDOSE, and then a guided application will be performed according to the specific area being treated.

• After: mild discomfort, a feeling of pressure, or transient pain. Basic care and progressive activity are indicated. The return times vary according to tissue and training load.

Safety depends on proper indication, aseptic technique, and consistent product. Recent literature emphasizes that, in addition to dose/concentration, the quality of the report and standardization are key to interpreting results and guiding patient expectations.

Integration with other regenerative approaches

In an integrated model, PRP does not travel alone. At Mitogenesis, we coordinate with:

• Rehabilitation/therapeutic exercise (the appropriate load "teaches" the tissue to use the PRP signal).

• Selected IV therapies to support recovery and oxidative stress (when applicable).

• Peptides with immunomodulatory or repair roles in specific cases, evaluated by the clinical team.

Why schedule Mitogenesis?

At Mitogenesis (Scottsdale, AZ), we work with a guiding question: what prevents your tissue from repairing? Sometimes it is poorly distributed mechanical load, other times, mitochondrial dysfunction, systemic stress, or poor sleep. That is why we combine clinical assessment, personalized interventions (like TruDOSE PRP), and education so you can measure progress realistically. Learn more about our work philosophy and why we prioritize personalization and follow-up.

PRP is not a single thing; it changes according to concentration, leukocytes, volume, and preparation. That is why dosing matters.

The main benefit of TruDOSE PRP is to turn a biological concept into a measurable and repeatable dose that is customized for your body, ensuring quality in every session.

Realistic expectations: better chances of consistency ≠ absolute promises. Integrate with rehabilitation, sleep, nutrition, and, if applicable, IVs or peptides under supervision.

Do you want an initial assessment to see if TruDOSE PRP makes sense for your case? Schedule at Mitogenesis (Scottsdale, AZ) and let us build a plan that measures what really matters to you (pain, function, and energy).

Sources:

ScienceDirect: The role of platelet-rich plasma in biomedicine: A comprehensive overview (https://www.sciencedirect.com/science/article/pii/S2589004224029328)

BioMed Research International: Current Challenges in the Development of Platelet-Rich Plasma-Based Therapies (https://onlinelibrary.wiley.com/doi/10.1155/2024/6444120)

The Journal of Bone and Joint Surgery: Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells (https://hub.jbjs.org/reader.php?rsuite_id=1285107&source=The_Journal_of_Bone_and_Joint_Surgery/99/10/809&topics=sm#info)

National Library of Medicine (NIH): Leukocytes Do Not Influence the Safety and Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis: A Double-Blind Randomized Controlled Trial (https://pmc.ncbi.nlm.nih.gov/articles/PMC11542329/)

Reviewed by:

Dr. Mel Schottenstein

Naturopathic Doctor

NMD, MBE, MScN, FICT, FSCT

Disclaimer: The information in this article is provided for informational purposes only and is not a substitute for the advice of your physician or other health care professional. Do not use the information to diagnose or treat a health problem or disease. Always consult with a healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem.

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